0 Southern diet could raise your risk of stroke

Eating Southern-style foods may be linked to a higher risk of stroke, according to research presented at the American Stroke Associations International Stroke Conference 2013.

In the first large-scale study on the relationship between Southern foods and stroke, researchers characterized a Southern diet by a high intake of foods such as fried chicken, fried fish, fried potatoes, bacon, ham, liver and gizzards, and sugary drinks such as sweet tea. In addition to being high in fat, fried foods tend to be heavily salted.

"Weve got three major factors working together in the Southern-style diet to raise risks of cardiovascular disease: fatty foods are high in cholesterol, sugary drinks are linked to diabetes and salty foods lead to high blood pressure," said Suzanne Judd, Ph.D., M.P.H., lead researcher and a nutritional epidemiologist at the University of Alabama Birminghams biostatistics department.

Previous research has shown that Southerners are about 20 percent more likely to have a stroke than the rest of Americans.

Comparing the dietary habits of more than 20,000 black and white adults, researchers found:

- Stroke frequency was directly proportional to how much Southern food participants ate.
- People who ate Southern foods about six times a week had a 41 percent higher stroke risk compared to those who ate it about once a month.
- Eating a Southern diet accounted for 63 percent of the higher risk of stroke among African-Americans above that of their white counterparts.
- Those whose diets were highest in fruits, vegetables, legumes and whole grains (eaten about five times a week) had a 29 percent lower stroke risk than those whose diets were the lowest in these foods (eaten about three times a week).

The study raises red flags for African-Americans who are five times more likely to eat Southern foods than whites, Judd said. And first-time stroke risk among blacks is almost double that of whites, according to American Stroke Association statistics.

Participants from 48 states answered telephone questionnaires about what foods they eat as part of the ongoing Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study (begun in 2003). Participants were evenly divided between men and women, and the minimum age was 45.

Each person underwent an in-person medical assessment including height, weight and blood pressure measurements; an electrocardiogram; and a blood test. Every six months after, participants answered follow-up telephone questions about their stroke incidence, sleep habits and overall health.

Researchers designed a mathematical model to group foods commonly eaten together into 56 different categories. Each persons eating habits were scored based on the categories. The scores were further analyzed in relation to how often they had a stroke.

About two-thirds of the participants who ate the most Southern-style foods lived in the southeastern United States. But, no matter where they live, people eating a lot of Southern foods should be more aware of their risks of stroke, Judd said.

Healthcare providers should educate patients about nutrition earlier, and ask patients about what theyre eating, how much and how often, she said.

0 Resveratrol could fight Alzheimers

The major genetic risk factor for Alzheimers disease (AD), present in about two-thirds of people who develop the disease, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one of the unsolved mysteries of AD is how ApoE4 causes the risk for the incurable, neurodegenerative disease. In research published this week in The Proceedings of the National Academy of Sciences, researchers at the Buck Institute found a link between ApoE4 and SirT1, an "anti-aging protein" that is targeted by resveratrol, present in red wine.

The Buck researchers found that ApoE4 causes a dramatic reduction in SirT1, which is one of seven human Sirtuins. Lead scientists Rammohan Rao, PhD, and Dale Bredesen, MD, founding CEO of the Buck Institute, say the reduction was found both in cultured neural cells and in brain samples from patients with ApoE4 and AD. "The biochemical mechanisms that link ApoE4 to Alzheimers disease have been something of a black box. However, recent work from a number of labs, including our own, has begun to open the box," said Bredesen.

The Buck group also found that the abnormalities associated with ApoE4 and AD, such as the creation of phospho-tau and amyloid-beta, could be prevented by increasing SirT1. They have identified drug candidates that exert the same effect. "This research offers a new type of screen for Alzheimers prevention and treatment," said Rammohan V. Rao, PhD, co-author of the study, and an Associate Research Professor at the Buck, "One of our goals is to identify a safe, non-toxic treatment that could be given to anyone who carries the ApoE4 gene to prevent the development of AD."

In particular, the researchers discovered that the reduction in SirT1 was associated with a change in the way the amyloid precursor protein (APP) is processed. Rao said that ApoE4 favored the formation of the amyloid-beta peptide that is associated with the sticky plaques that are one of the hallmarks of the disease. He said with ApoE3 (which confers no increased risk of AD), there was a higher ratio of the anti-Alzheimers peptide, sAPP alpha, produced, in comparison to the pro-Alzheimers amyloid-beta peptide. This finding fits very well with the reduction in SirT1, since overexpressing SirT1 has previously been shown to increase ADAM10, the protease that cleaves APP to produce sAPP alpha and prevent amyloid-beta.

AD affects over 5 million Americans – there are no treatments that are known to cure, or even halt the progression of symptoms that include loss of memory and language. Preventive treatments are particularly needed for the 2.5% of the population that carry two genes for ApoE4, which puts them at an approximate 10-fold higher risk of developing AD, as well as for the 25% of the population with a single copy of the gene. The group hopes that the current work will identify simple, safe therapeutics that can be given to ApoE4 carriers to prevent the development of Alzheimers disease.

0 Technocrats Running Amok What It Could Mean For America Inc

Check out The New York Times columnist David Brooks most recent article for an insightful look at how the Europeans entrusted their collective economic future to an expert technocratic class.  Once those mandarins were unleashed, their bureaucratic disdain for undereducated commoners was only exceeded by their skill at complex obfuscation.  Egads.

On the other side of the globe, Chinas state-managed businesses are making a mess of high speed rail, creating a housing bubble and are enabling an autonomous Peoples Liberation Army.  And last but not least, the Russians have taken the concept of state sponsored oligarchy to a whole new level.

Compared to the rest of the world, carrying mortgages, automobile manufacturers and solar panel plants on the U.S. balance sheet may just have to be a new way of doing business.  If thats the case, well also need our pool of cool, pedigreed, hyper-educated Masters of the Universe like Energy Secretary Mr. Chu, who can easily triangulate on policy, politics and returns on investment. Thanks to brainy virtuosos like him, Uncle Sam, Inc. will be able to roll the dice and be a venture capitalist. 

And health insurance isnt immune. The virtuosos in Washington are busy setting the essential benefit, determining the best medical loss ratio and which companies can compete in exchanges.  Generics are regulated and if there is no approval, drugs wont be covered.  Even though elections have consequences and Disease Management Care Blog readers may loyally disagree from time to time, how can we turnips dare to cross swords with experts like this?

Its ironic that with this as background, our political class can claim to understand the concerns of "Occupy Wall Street."  So does the DMCB, but that doesnt mean it isnt also worrying about those elite technocrats helping Washington become Wall Street.