0 Resveratrol could fight Alzheimers

The major genetic risk factor for Alzheimers disease (AD), present in about two-thirds of people who develop the disease, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one of the unsolved mysteries of AD is how ApoE4 causes the risk for the incurable, neurodegenerative disease. In research published this week in The Proceedings of the National Academy of Sciences, researchers at the Buck Institute found a link between ApoE4 and SirT1, an "anti-aging protein" that is targeted by resveratrol, present in red wine.

The Buck researchers found that ApoE4 causes a dramatic reduction in SirT1, which is one of seven human Sirtuins. Lead scientists Rammohan Rao, PhD, and Dale Bredesen, MD, founding CEO of the Buck Institute, say the reduction was found both in cultured neural cells and in brain samples from patients with ApoE4 and AD. "The biochemical mechanisms that link ApoE4 to Alzheimers disease have been something of a black box. However, recent work from a number of labs, including our own, has begun to open the box," said Bredesen.

The Buck group also found that the abnormalities associated with ApoE4 and AD, such as the creation of phospho-tau and amyloid-beta, could be prevented by increasing SirT1. They have identified drug candidates that exert the same effect. "This research offers a new type of screen for Alzheimers prevention and treatment," said Rammohan V. Rao, PhD, co-author of the study, and an Associate Research Professor at the Buck, "One of our goals is to identify a safe, non-toxic treatment that could be given to anyone who carries the ApoE4 gene to prevent the development of AD."

In particular, the researchers discovered that the reduction in SirT1 was associated with a change in the way the amyloid precursor protein (APP) is processed. Rao said that ApoE4 favored the formation of the amyloid-beta peptide that is associated with the sticky plaques that are one of the hallmarks of the disease. He said with ApoE3 (which confers no increased risk of AD), there was a higher ratio of the anti-Alzheimers peptide, sAPP alpha, produced, in comparison to the pro-Alzheimers amyloid-beta peptide. This finding fits very well with the reduction in SirT1, since overexpressing SirT1 has previously been shown to increase ADAM10, the protease that cleaves APP to produce sAPP alpha and prevent amyloid-beta.

AD affects over 5 million Americans – there are no treatments that are known to cure, or even halt the progression of symptoms that include loss of memory and language. Preventive treatments are particularly needed for the 2.5% of the population that carry two genes for ApoE4, which puts them at an approximate 10-fold higher risk of developing AD, as well as for the 25% of the population with a single copy of the gene. The group hopes that the current work will identify simple, safe therapeutics that can be given to ApoE4 carriers to prevent the development of Alzheimers disease.

0 Five Step Alzheimers Prevention Plan

Five Step Alzheimers Prevention Plan - Maybe you forgot where you set your keys. It happens to everyone, right? But what about forgetting a good friend’s name? Or an important appointment? Left on its own, your brain actually begins to shrink when you hit midlife.

Whether you’ve had a family member who’s suffered from Alzheimer’s, you’re starting to notice your memory is not as sharp as it used to be, or you want to protect yourself for the future, it’s time to strengthen your brain. Research now shows that you can not only slow down brain shrinkage, but you can actually increase the size of our brain at any age. Here, Dr. Oz and renowned neurologist Dr. Majid Fotuhi reveal their memory cure – a miracle plan to help you prevent Alzheimer’s in just five simple steps.  

Brain Booster 1: DHA Supplement

If you’re only going to take one supplement, DHA is the one you need. DHA, or docosahexaenoic acid, is an omega-3 fatty acid that makes up a significant portion of your brain tissue. Lower DHA levels are associated with a smaller brain size, so it’s important to supplement your natural DHA intake (which comes primarily from cold-water seafood). Taking a DHA supplement reduces inflammation, combats the plaque buildup associated with Alzheimer’s, and increases blood flow to your brain. In fact, studies have shown that taking 600mg of DHA supplement daily for 6 months boosts your brain so much that it functions as though it were 3 years younger!

Brain Booster 2: Brain Stimulating Switch-Ups

Just as it’s important to add variety to your physical exercise routine, adding variety to your daily mental routine cross-trains different muscles in your brain. Simple switch-ups, such as putting your watch on your opposite wrist, using your opposite hand while brushing your teeth, doing your hair and eating, and even writing backward activate brain regions that might otherwise go unstimulated. This stimulation can lower your risk of memory impairment and Alzheimer’s disease.  

Brain Booster 3: The 7-7-7 Stress-Busting Breath

We all know stress is bad for our health, but you may not have known it can be deadly when it comes to your brain. Stress is like poison for your hippocampus – the part of brain responsible for memory – as it leads to chronically high levels of the hormone cortisol. High cortisol levels can cause brain cell dysfunction, kill brain cells, and cause atrophy of the brain. Busting stress, theore, is vital to preserve your memory.Three times a day, close the door, remove your shoes and socks, and lower the lights. Breathe in for 7 seconds; hold it for another 7; then exhale for a final 7 seconds. Repeat the technique seven times to help “reset” your brain and get your cortisol levels under control. Research has shown that mindful relaxation techniques are associated with an increase in the size of your hippocampus in as little as 8 weeks.

Brain Booster 4: Tease Your Memory

While we may feel our memories just aren’t what they used to be, we actually have an innate ability to remember just about anything – so long as we train ourselves to use the right mechanisms. It may shock you, but you have the ability to memorize a list of 20 or 30 items, simply by forming big, important, or even silly associations with each item. For example, say you need to remember the word “baker.” If you think of a friend with the last name “Baker” you may have some success. If, however, you think of a bread baker, wearing a white hat and apron, doused in flour, surrounded by the aroma of freshly baked croissants, you won’t forget the word “baker” for days! You can do the same with a shopping list, a to-do chart, or just about anything, so long as you associate high-importance with all 20 items. Doing so will have a positive, expansive effect on your hippocampus, fighting off Alzheimers.

Brain Booster 5: Brain Push-Ups

Dr. Fotuhi believes push-ups – yes, just good old-fashioned push-ups – are the most important step to strengthening your “brain muscles” and preventing Alzheimer’s. Proper form, however, is key. Start on the floor, with your hands set at about a shoulder-width distance, angling your hands in a way that feels comfortable. Extend your legs, with your feet also in a comfortable position, generally shoulder-width apart or wider for more stability. Be sure your body is in one straight line from your head to your heels; avoid having your butt or belly either sagging or sticking up. Clenching your butt cheeks and tightening your abs will ensure you’ve engaged your core. Keeping your gaze forward, slowly lower until your elbows form a 90-degree angle, keeping your arms in tight to your body. Then, push yourself back up, still keeping your elbows tight and your core engaged. For additional support when first starting out, keep your knees bent on the floor and do modified push-ups. Either way, 7 push-ups or more a day will help stimulate blood flow to your brain and generate new brain cells, which is the most effective weapon in fighting cognitive disease.

0 Alzheimers Disease Prevention and Treatment

Alzheimers Disease cases have been rapidly increasing over the last half century, and are currently the seventh leading cause of death in America.  Alzheimers is the most common form of dementia and affects our ability to form memories, communicate and perform the most common daily tasks.  Fifty years ago, Alzheimers Disease was virtually unknown to medical science, yet today we see a skyrocketing incidence of this devastating affliction.  While there is a genetic component to the disease, it is largely the result of lifestyle, poor diet and environmental factors which cause systemic inflammation in the body.

Alzheimers Disease Caused by Brain Inflammation

The Standard American Diet is known to promote a low grade inflammation throughout the body, and is linked with heart disease, stroke and cancer.  We can add Alzheimers Disease to the list, as the brain is susceptible to the ravages of inflammatory chemicals which are released into the blood as a result of poor diet and environmental assault.

The disease is characterized by the accumulation of a protein known as beta amyloid which blocks communications between the neurons synapses.  Normally the brain is able to break down the amyloid plaques so they can be removed properly, but this function becomes limited as inflammation affects the normal plaque clearance process in the brain.  Alzheimers was a very rare condition prior to 1950.  Our diet did not include all the ined, processed and fried foods.  Meals were made at home from natural ingredients including plenty of fresh fruits and vegetables, and we were not continually exposed to a barrage of unhealthy chemicals and pollutants in our homes and the environment.

Anti-Aging Formula Increases Brain Synapse Formation

Scientists have been working feverishly on drugs and natural nutraceuticals which may have an impact on the development and progression of Alzheimers Disease.  There are several drugs which have been approved for management of the disease, but they are at best palliative.  Recent studies have demonstrated that a specially formulated cocktail consisting of uridine, choline and the Omega-3 fatty acid DHA helped the brain to form new synapses for communication between neurons.  

DHA is especially important for brain health, as more than half of the brain cell membranes are composed of the fat.  When DHA is in short supply in the blood, other inferior fats must be used for the construction process resulting in a cell which cannot function optimally.  Also important to the formula for synapse development in the brain are the B Vitamins, especially the B-12 derivative Methylcobalamin which provides the electrical charge that cause the synapse to fire.  This is an important finding for those wishing to prevent and even treat Alzheimers Disease since the more healthy synapses which exist in the brain, the better we can process, store and manipulate information and memories.

Targeted Supplements Inhibit Plaque Formation

The most exciting research involves two critical nutrients, which when combined have been shown to reduce the amount of beta amyloid plaque formation in the brain.  Resveratrol and Circumin when taken together can reduce plaque deposits.  While there is controversy as to whether beta amyloid protein is the cause or effect of Alzheimers Disease, there is little argument that clearing this sticky substance from the brain is the key to prevention and even treatment.  Resveratrol is an extract from the skins of red grapes which has the ability to break apart amyloid deposits.  Circumin is a natural component of the spice curry, and is a powerful antioxidant.  Working synergistically with Resveratrol, the two provide a powerful punch to plaque formation, and given their excellent safety record, should be a part of every dietary program to prevent Alzheimers Disease.

Lifestyle has been shown to be a key component in the development of Alzheimers Disease.  Diet and our environment have changed dramatically over the past decades, and are the primary cause of the rampant increase in the disease.  Drug manufacturers are working hard to find the magic bullet which will cure this disease, yet the best tools we have for prevention are realized by following a healthy diet, caul monitoring of the chemical environment to which we are subjected each day and supplementing with a targeted group of nutraceuticals which are essential to healthy brain function.

0 Less Sweet Foods To Avoid Alzheimers

Unhealthy diet as fond of sweets and processed foods have been shown to increase the risk of type 2 diabetes. But recent research suggests that it is also at risk for Alzheimers disease or diabetes are often mentioned type 3.
 
The bodys cells need glucose from food for energy. The hormone insulin produced in the pancreas to help the bodys cells take up glucose from the blood stream, where the cells then process it into energy.If there is excess glucose in the bloodstream from eating too much sweet food, the pancreas produces more insulin so that insulin resistance in the cells of the body can be increased.  
If the cells in the brain also becomes resistant to insulin, the brain does not get enough energy and his condition could worsen. Brain cells are starved of energy can lead to memory loss and confusion are symptoms of Alzheimers disease.But its never too late to protect the brain from Alzheimer threat. We are recommends the following precautions:

1. Keep your body weight to remain stable
If you weigh and measure waist circumference regularly, youll know if your weight has increased or not. So you can prevent obesity early on. Obesity is also linked to insulin resistance.

2. Eat less meat
With a diet of plant-based foods, such as fruits, vegetables, whole grains, and reducing the consumption of meat can make the body more healthy and avoid obesity.

3. Reduce consumption of sugar 
Sugar has been linked to diabetes type 2 and 3, so you need to eat less everyday. Avoid eating packaged foods often contain artificial sweeteners.

4. Cooking meals at home 
By cooking your own meals, you can assure yourself the materials you use are the best and healthier.

5. Avoid nitrate
Research shows that there is a link between Alzheimers with the consumption of foods containing nitrosamines. Protect yourself by avoiding processed foods that contain nitrates on the label. Processed foods include cheese, hot dogs, beef, and bacon.

0 Vitamin B Daily expel Effective Alzheimers

Health for human | received information that RESEARCHERS at the University of Oxford found that taking daily doses of vitamin B6, B12, and folic acid in a single pill to reduce the risk of brain shrinkage over 30 percent in older people with mild memory problems.

Some types of vitamin B is known to control the levels of amino acid and homocysteine ​​in the blood. High levels of homocysteine ​​associated with an increased risk of Alzheimers.

The study participants were asked to consume a pill containing 0.5 mg of vitamin B12, 20 mg vitamin B6, and 0.5 mg of folic acid or placebo. They were also asked to undergo cognitive tests over the past two years. Their brains were then scanned at the beginning and end of the study.

The findings of this study presented by neuropsi, as quoted from Yahoo on Wednesday (14 / 9). Dr de Jager says, "The higher level of homocysteine ​​in the blood, the better the response to treatment. We still need more research to show that this method can actually dispel dementia."

A spokesman for the Alzheimer Komuitas said, "We know the importance of getting enough vitamins. However, the best way to reduce the risk of dementia is to exercise regularly and eat healthy foods with lots of fruits and vegetables. Just as important, namely blood pressure and cholesterol checked regularly. "(Pri/OL-06)