0 Green Tea Affects Genes to Improve Cholesterol Metabolism

Green tea consumption has been shown to benefit many health issues ranging from help with weight management to cancer prevention and treatment. New research publishedin the British Journal of Nutritionexplains that the natural extract from the Camellia sinensis plant has a powerful effect on cholesterol metabolism in the human body.

Most forward thinking health professionals now understand that dysfunction in the LDL cholesterol pathway lays the foundation for cardiovascular health problems, cancer and fatty liver disease. Regular green tea consumption is now shown to improve healthy LDL cholesterol function, enabling the fatty molecule to efficiently usher excess cholesterol from the body and improve risk factors for many chronic disease conditions.

Green Tea Alters Gene Expression Lower LDL Cholesterol Levels

In one of the first studies of its type, researchers performed DNA microarray analysis to examine the effect of the active compound found in green tea called epigallocatechin gallate (EGCG). Scientists specifically targeted the catechin to determine their effect on cholesterol metabolism in HepG2 hepatocytes. They determined that the expression levels of several genes related to cholesterol metabolism, including the LDL receptor, were changed by EGCG treatment.

EGCG was found to boost the function of the LDL receptor on liver cells. Researchers commented“This is very important as proper function of the LDL receptor enables your liver to “capture” circulating LDL and recycle it.”  In this study, green tea is shown to alter gene expression toward healthy LDL cholesterol metabolism by improving receptor acceptance by the liver. The liver displays an improved capacity to capture and filter LDL cholesterol for removal from the body.

Green Tea Improves Biomarkers to Lower Heart Disease, Cancer and Dementia Risks

In addition to the finding that green tea alters LDL cholesterol metabolism, ECGC was found to inhibit genes to reduce the production of Apolipoprotein B (ApoB). ApoB formation is required to initially form LDL molecules in the blood. Excess production of ApoB is a significant marker for chronic illnesses ranging from cardiovascular disease and heart attack to increased risk of cancer and dementia.

Green tea and the active compound EGCG are quickly ascending to nutritional “superstar” status. The Chinese have extolled its virtues for countless generations. Researchers now document the prowess of this nutrient by scientifically validating the direct impact exerted on our genetic structure to affect healthy cholesterol function and removal from the body. The healthy benefits of green tea are realized by drinking several fresh brewed cups of organically harvested leaves each day or supplementing with 250 to 500 mg of EGCG extract.

0 How Food Controls Your Genes and Health

Weve always heard the timeless adage, you are what you eat, but most people dont realize that the foods we consume every day have a dramatic effect on the basic mechanism which controls our existence, our genes.  Now that we have decoded the human genome, scientists have been able to discover the nimble ability of our genes to react to the foods we eat in a newly evolving field known as nutrigenomics, which has either a positive or negative impact on the way we live today.

Food Directly Controls Our Genes

Medical researchers now have the ability to watch specific genes and groups of genes which switch on and off based on external triggers such as pollutants, internally ingested foods and even factors such as stress.  The surprising fact about nutrigenomics is the discovery that individual food items have an immediate effect on the regulation of our genes.  Many had believed that our genes were static in nature, that is they required many generations to alter, and the genes we were born with were the genes we died with.

But our genes really are dynamic.  They are continually influenced by many factors and food is among the most powerful controlling mechanism.  Using genetic material extracted from blood, scientists are able to see the changes to specific gene groups after eating a single meal.  A Standard American Diet meal consisting of a bacon cheeseburger, fries and a shake have an instant and immediate negative effect on the bodys controlling mechanism.  Conversely, a meal of raw, dark leafy greens, broccoli, lean protein and natural fats will have an up-regulating healthy impact on our genes.  The fact that we are able to watch gene regulation in virtual real-time demonstrates to us the importance of nutrigenomics, as we understand that we can change our health through dietary modification in a very short period of time.

Diet Can Be Used As Medicine

While a small percentage of our genetic predisposition toward certain diseases is inherited, most forward-thinking people understand that lifestyle choices and diet can modify and positively impact our health.  Many raw, natural vegetables, nuts, seeds and legumes contain phytonutrients which the body interprets as a trigger mechanism for the switching of our genes.  As the body breaks down these foods, the thousands of nature-created vitamins, minerals and specific plant chemicals are released and absorbed by the cells.  These compounds have been found to directly influence how the cellular DNA replicates and transcribes newly created proteins which are the building blocks for the cellular structure of the body.

This is a critical step in disease proliferation if some part of the process goes awry.  As more is uncovered about the power of different foods, and the specific organs which they may influence, the rapidly emerging field of nutrigenomics will be used as a form of medicine, with counselors prescribing a very specific regimen to help prevent or even treat a specific condition.

Super Foods as Pharmaceuticals

Super-foods such as broccoli and the cruciferous vegetable family have been studied for their unique ability to affect cellular proliferation in the prostate and breast.  The sulfur based compound sulforaphane is released when the vegetable is eaten, and small quantities have been found to have a significant impact on gene expression.  Many foods have been found to contain nutrients which affects how our body functions.  When we deprive ourselves of these natural food items, we set forward a cascade of potential health issues such as heart disease, cancer, Alzheimers, diabetes and stroke.

As we learn to make natural, healthy dietary choices our body responds almost immediately.  Results of these changes can be seen at the cellular level in as little as two weeks, and over the course of several months, people have been able to make life altering changes to their health.  Now that the human genome has been mapped, we can determine the function of each gene and which food nutrients are best suited to provide an impact on a specific health concern.  A diet of ined carbohydrates, wheat and corn products, sugar, high fructose corn syrup and trans fats (the Standard American Diet - SAD), is the course to a lifetime of disease.  Foods eaten the way nature provides, raw vegetables, limited fruits, nuts, seeds, legumes and lean protein are the medicine of the future and can provide a miraculous new road toward your healthy lifestyle.

0 Role of Genes Mesothelin in Cancer Establishment

Role of Genes Mesothelin - The Researcher from Japan, latest have research the mechanism from gen mesothelin that get effect of malignant mesothelioma. This study published in doctoral journal of Human Pathology.

Mesothelioma is a rare cancer that occurs almost entirely caused by exposure to asbestos. Since there is no cure for this disease, life expectancy for most mesothelioma patients ranged between four and 18 months after diagnosis of mesothelioma is known for sure. Although there is no cure to date, some patients who are diagnosed early mesothelioma can be given a combination of aggressive therapy, such as surgery, chemotherapy and radiation. Combination therapy, known as multimodality therapy, currently has the best chance to prolong the life of the patient.

The studys authors explain, "Gene methylation led to the development of malignant tumors in several tumor [malignant mesothelioma] are histologically divided into 3 subtypes, namely, epithelioid, sarcomatoid, and biphasic type, and it shows that mesothelin expression is restricted to epithelioid type and the epithelioid component of biphasic MM type (malignant mesothelioma). However, the mechanism of expression regulation has not been clarified. "