Showing posts with label role. Show all posts
Showing posts with label role. Show all posts

Thursday, January 16, 2014

0 Moderate alcohol intake and cancer the role of under reporting



A large US cohort study in 129,987 persons suggests that the apparent increased risk of cancer among light-moderate drinkers is substantially due to underreporting of intake.

Although experts agree that heavy consumption of alcohol is related to increased risk of several cancer types, the role of light-to-moderate drinking is less clear, said Dr Arthur Klatsky of Kaiser Permanente Medical Care Program, Oakland, CA, USA. Some studies have suggested there is a connection, while others have found no link.

The results of the new analysis suggest that any apparent relationship between cancer risk and light-to-moderate drinking, meaning up to 2 standard sized drinks per day for men and one for women, may be largely an artifact of under-reporting—that is, lying about drinking amount.

"If some heavy drinkers answer surveys saying that they only drink lightly, the effects of heavy drinking then appear to be related to light-to-moderate intake," Dr Klatsky explained. "Our analysis inferentially supports this factor in our study population and it is probably applicable to most studies, as under-reporting of alcohol consumption is surely prevalent."

"There are plenty of reasons why people need to avoid heavy drinking, but these do not generally apply to light drinking," Dr Klatsky said. "All concerns about the risks of light drinking need to be balanced by the evidence that persons at risk of heart disease benefit from lighter alcohol drinking. This --with plenty of exceptions-- means most persons over 50."

Wednesday, November 20, 2013

0 Role of Genes Mesothelin in Cancer Establishment

Role of Genes Mesothelin - The Researcher from Japan, latest have research the mechanism from gen mesothelin that get effect of malignant mesothelioma. This study published in doctoral journal of Human Pathology.

Mesothelioma is a rare cancer that occurs almost entirely caused by exposure to asbestos. Since there is no cure for this disease, life expectancy for most mesothelioma patients ranged between four and 18 months after diagnosis of mesothelioma is known for sure. Although there is no cure to date, some patients who are diagnosed early mesothelioma can be given a combination of aggressive therapy, such as surgery, chemotherapy and radiation. Combination therapy, known as multimodality therapy, currently has the best chance to prolong the life of the patient.

The studys authors explain, "Gene methylation led to the development of malignant tumors in several tumor [malignant mesothelioma] are histologically divided into 3 subtypes, namely, epithelioid, sarcomatoid, and biphasic type, and it shows that mesothelin expression is restricted to epithelioid type and the epithelioid component of biphasic MM type (malignant mesothelioma). However, the mechanism of expression regulation has not been clarified. "
 

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